Journal
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
Volume 24, Issue 5, Pages 405-423Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911509341774
Keywords
biocompatibility; hydroxyapatite; injectable hydrogels; poly(ethylene glycol) dimethacrylate; tissue engineering
Funding
- Program for Changjiang Scholars and Innovative Research Team in University
- Key Lab. of Beijing City
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Injectable hydrogels are attractive materials for tissue engineering as they provide fast reaction rates, low heat release, and biocompatibility for cell proliferation and permanent interface with surrounding tissue. A series of injectable poly(ethylene glycol) dimethacrylate (PEGDMA) hydrogels with four different weight fractions of hydroxyapatite (HA) particles were prepared and thermal and mechanical properties evaluated. The cytocompatibility was assessed by examining the viability and morphology of human mesenchymal stem cells (hMSCs) seeded on the hydrogels. The in situ crosslink process displayed a vast decrease in the maximal temperature and an increase in the maximal temperature time. Cytocompatibility evaluation by MTT assay, scanning electron microscopy (SEM) and laser scanning confocal microscopy (LSCM) showed that the cells on the composite hydrogels possessed better viability and adherence than the hydrogels without HA. The results indicated that composite hydrogels have potential as injectable materials for tissue engineering application.
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