Journal
JOURNAL OF BASIC MICROBIOLOGY
Volume 48, Issue 2, Pages 99-103Publisher
WILEY
DOI: 10.1002/jobm.200700292
Keywords
Aspergillus; farnesol; conidiation; quorum sensing
Categories
Ask authors/readers for more resources
Farnesol was the first quorum-sensing regulator to be found in eukaryotic cells. In Candida albicans, a dimorphic fungal human pathogen, farnesol blocks the yeast-to-filamentous growth transition. Here we show that in Aspergillus niger farnesol acts as an inhibitor of conidiation: Colonies grown on media containing farnesol were unable to develop conidia. Although farnesol treated A. niger cultures exhibited a colony morphology resembling the fluffy phenotype of A. nidulans, which is caused by a hyperactive G-protein/cAMP pathway, the intracellular level of cAMP in A. niger mycelia grown in presence of farnesol is greatly diminished. Furthermore, whereas inhibiting adenylyl cyclase led to a farnesol-like effect, the addition of external cAMP inhibited conidiation without causing a fluffy phenotype. This suggests that the mechanisms regulating conidiation in A. niger and A. nidulans are different.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available