Journal
NATURE REVIEWS NEUROSCIENCE
Volume 16, Issue 9, Pages 564-574Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3983
Keywords
-
Categories
Funding
- Wellcome Trust Strategic Award [098330/Z/12/Z]
- Medical Research Council [U117527252]
- Alzheimer Research UK
- Alzheimer Society
- Bailey Thomas Trust
- Epilepsy Research UK
- Lee Kong Chian School of Medicine
- Nanyang Technological University Start-up Grant
- Singapore Ministry of Education Academic Research Fund Tier 1 [2014-T1-001-173]
- Wellcome Trust [098327/Z/12/Z] Funding Source: Wellcome Trust
- MRC [G0601056] Funding Source: UKRI
- Alzheimer's Society [192] Funding Source: researchfish
- Epilepsy Research UK [PGE1301] Funding Source: researchfish
- Medical Research Council [G0601056] Funding Source: researchfish
- The Francis Crick Institute [10194, 10197] Funding Source: researchfish
- Wellcome Trust [098327/Z/12/Z] Funding Source: researchfish
Ask authors/readers for more resources
Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that this risk is conferred by the presence of three copies of the gene encoding amyloid precursor protein (APP)-an Alzheimer disease risk factor-although the possession of extra copies of other chromosome 21 genes may also play a part. Further study of the mechanisms underlying the development of Alzheimer disease in people with Down syndrome could provide insights into the mechanisms that cause dementia in the general population.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available