Journal
NATURE REVIEWS NEUROSCIENCE
Volume 16, Issue 4, Pages 201-212Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3879
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Funding
- European Research Council [260463]
- Max Planck Society - Weizmann Institute of Science Laboratory for Experimental Neuropsychiatry and Behavioral Neurogenetics
- Israel Science Foundation [803/11]
- Roberto and Renata Ruhman
- Nella and Leon Benoziyo Center for Neurological Diseases
- Henry Chanoch Krenter Institute for Biomedical Imaging and Genomics
- Perlman Family Foundation
- Adelis Foundation
- Marc Besen
- Pratt Foundation
- Irving I. Moskowitz Foundation
- European Research Council (ERC) [260463] Funding Source: European Research Council (ERC)
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Recent studies have revealed that patients with psychiatric disorders have altered microRNA (miRNA) expression profiles in the circulation and brain. Furthermore, animal studies have shown that manipulating the levels of particular mi-RNAs in the brain can alter behaviour. Here, we review recent studies in humans, animal models, cellular systems and bioinformatics that have advanced our understanding of the contribution of brain mi-RNAs to the regulation of behaviour in the context of psychiatric conditions. These studies highlight the potential of miRNA levels to be used in the diagnosis of psychiatric disorders and suggest that brain mi-RNAs could become novel treatment targets for psychiatric disorders.
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