Journal
NATURE REVIEWS NEUROSCIENCE
Volume 16, Issue 8, Pages 445-457Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3921
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Funding
- UCI ICTS
- ADRC Pilot Project Awards
- Pediatric Hydrocephalus Foundation
- Alfred P. Sloan Foundation
- NIH [K99/R00 NS072192]
- [CIRM RN2-00915-1]
- [R01 NS088566]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [K99NS072192, R00NS072192, R01NS088566] Funding Source: NIH RePORTER
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The choroid plexus (ChP) is the principal source of cerebrospinal fluid (CSF), which has accepted roles as a fluid cushion and a sink for nervous system waste in vertebrates. Various animal models have provided insights into how the ChP-CSF system develops and matures. In addition, recent studies have uncovered new, active roles for this dynamic system in the regulation of neural stem cells, critical periods and the overall health of the nervous system. Together, these findings have brought about a paradigm shift in our understanding of brain development and health, and have stimulated new initiatives for the treatment of neurological disease.
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