Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 59, Issue 3, Pages 1756-1759Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.04773-14
Keywords
-
Categories
Funding
- Dipexium Pharmaceuticals Inc.
- Achaogen
- Actelion
- Affinium
- American Proficiency Institute (API)
- AmpliPhi Bio
- Anacor
- Astellas
- AstraZeneca
- Basilea
- BioVersys
- Cardeas
- Cempra
- Cerexa
- Cerexa, Cubist
- Daiichi
- Dipexium
- Durata
- Exela
- Fedora
- Forest Research Institute
- Furiex
- Genentech
- GlaxoSmithKline
- Janssen
- Johnson Johnson
- Medpace
- Meiji Seika Kaisha
- Melinta
- Merck
- Methylgene
- Nabriva
- Nanosphere
- Novartis
- Pfizer
- Polyphor
- Rempex
- Roche
- Seachaid
- Shionogi
- Synthes
- Medicines Co.
- Theravance
- Thermo-Fisher
- Venatorx
- Vertex
- Waterloo
- Wockhardt
Ask authors/readers for more resources
Pexiganan, a 22-amino-acid synthetic cationic peptide, is currently in phase 3 clinical trials as a topical antimicrobial agent for the treatment of mild infections associated with diabetic foot ulcers. Bacterial isolates from the 2013 SENTRY Antimicrobial Surveillance Program designated as pathogens from diabetic foot infections (DFI) and Gram-negative and -positive pathogens from various infection types that harbored selected resistance mechanisms/phenotypes were tested against pexiganan in reference cation-adjusted Mueller-Hinton broth. The MIC50 and MIC90 against all organisms tested from DFI were 16 and 32 mu g/ml, respectively. Escherichia coli, Klebsiella pneumoniae, Citrobacter koseri, Enterobacter cloacae, Acinetobacter species, and Pseudomonas aeruginosa MIC values ranged from 8 to 16 mu g/ml. Pexiganan MIC values among Staphylococcus aureus (methicillin-resistant S. aureus [MRSA] and methicillin-susceptible S. aureus [MSSA]), beta-hemolytic streptococci, and Enterococcus faecium ranged from 8 to 32 mu g/ml. Pexiganan activity was not adversely affected for members of the family Enterobacteriaceae or P. aeruginosa that produced beta-lactamases or resistance mechanisms to other commonly used antimicrobial agents. Decreased susceptibility to vancomycin did not affect pexiganan activity against S. aureus or E. faecium. Enterococcus faecalis appears to be intrinsically less susceptible to pexiganan (MIC, 32 to 256 mu g/ml). The all organism MIC90 of 32 mu g/ml for pexiganan in this study was > 250-fold below the pexiganan concentration in the cream/delivery vehicle being developed for topical use.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available