Journal
NATURE REVIEWS NEUROSCIENCE
Volume 16, Issue 2, Pages 69-78Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrn3858
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Funding
- Agence Nationale pour la Recherche
- Sorbonne Universites
- Universite Pierre-et-Marie-Curie
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Centre National de la Recherche Scientifique (CNRS)
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Chemokines and opioids are important regulators of immune, inflammatory and neuronal responses in peripheral and central pain pathways. Recent studies have provided insights into the functional interactions between chemokine receptors and opioid receptors, and their role in pain modulation. In this Progress article, we discuss how crosstalk between these two systems might provide a molecular and cellular framework for the development of novel analgesic therapies for the management of acute and/or chronic pain.
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