Journal
JOURNAL OF BACTERIOLOGY
Volume 194, Issue 8, Pages 2020-2026Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.06243-11
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Funding
- NIH [AI057512]
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
- Institute of Pathogen Biology, Chinese Academy of Medical Sciences
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Yersinia pestis, which causes bubonic plague, forms biofilms in fleas, its insect vectors, as a means to enhance transmission. Biofilm development is positively regulated by hmsT, encoding a diguanylate cyclase that synthesizes the bacterial second messenger cyclic-di-GMP. Biofilm development is negatively regulated by the Rcs phosphorelay signal transduction system. In this study, we show that Rcs-negative regulation is accomplished by repressing transcription of hmsT.
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