4.4 Article

Pseudomonas aeruginosa tssC1 Links Type VI Secretion and Biofilm-Specific Antibiotic Resistance

Journal

JOURNAL OF BACTERIOLOGY
Volume 193, Issue 19, Pages 5510-5513

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00268-11

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Funding

  1. Natural Sciences and Engineering Research Council of Canada
  2. Canadian Cystic Fibrosis Foundation

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Biofilm-specific antibiotic resistance is influenced by multiple factors. We demonstrated that Pseudomonas aeruginosa tssC1, a gene implicated in type VI secretion (T6S), is important for resistance of biofilms to a subset of antibiotics. We showed that tssC1 expression is induced in biofilms and confirmed that tssC1 is required for T6S.

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