4.4 Article

TdaA Regulates Tropodithietic Acid Synthesis by Binding to the tdaC Promoter Region

Journal

JOURNAL OF BACTERIOLOGY
Volume 193, Issue 15, Pages 4002-4005

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00323-11

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Funding

  1. National Science Foundation [IOS-0842331]

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Silicibacter sp. TM1040, a member of the marine Roseobacter clade, produces the antibiotic and quorum signaling molecule tropodithietic acid (TDA), encoded by tdaABCDEF. Here, we showed that an LysR-type transcriptional regulator, TdaA, is a positive regulator of tdaCDE gene expression and binds to the tdaC promoter region.

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