4.4 Article

Chemotaxis to the Quorum-Sensing Signal AI-2 Requires the Tsr Chemoreceptor and the Periplasmic LsrB AI-2-Binding Protein

Journal

JOURNAL OF BACTERIOLOGY
Volume 193, Issue 3, Pages 768-773

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.01196-10

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Funding

  1. NSF [CBET 0846453]
  2. NIH [R01 GM089999]
  3. Bartoszek Fund for Basic Biological Science
  4. Direct For Biological Sciences
  5. Div Of Molecular and Cellular Bioscience [1121916] Funding Source: National Science Foundation
  6. Directorate For Engineering
  7. Div Of Chem, Bioeng, Env, & Transp Sys [0846453] Funding Source: National Science Foundation

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AI-2 is an autoinducer made by many bacteria. LsrB binds AI-2 in the periplasm, and Tsr is the L-serine chemoreceptor. We show that AI-2 strongly attracts Escherichia coli. Both LsrB and Tsr are necessary for sensing AI-2, but AI-2 uptake is not, suggesting that LsrB and Tsr interact directly in the periplasm.

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