4.4 Article

The PpaA/AerR Regulators of Photosynthesis Gene Expression from Anoxygenic Phototrophic Proteobacteria Contain Heme-Binding SCHIC Domains

Journal

JOURNAL OF BACTERIOLOGY
Volume 192, Issue 19, Pages 5253-5256

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00736-10

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Funding

  1. National Institutes of Health National Center for Research Resources [P20 RR15640]
  2. National Research Initiative of the United States Department of Agriculture Cooperative State Research, Education and Extension Service [2002-35318-14039]
  3. Welch Foundation [I-1575]
  4. National Science Foundation [620531]

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The SCHIC domain of the B-12-binding domain family present in the Rhodobacter sphaeroides AppA protein binds heme and senses oxygen. Here we show that the predicted SCHIC domain PpaA/AerR regulators also bind heme and respond to oxygen in vitro, despite their low sequence identity with AppA.

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