Journal
NATURE REVIEWS NEUROLOGY
Volume 11, Issue 7, Pages 371-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrneurol.2015.103
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Funding
- Danish Multiple Sclerosis Society
- Johnson Foundation
- Warwara Larsen Foundation
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A recent study has identified a variant of the SLC9A9 gene that is associated with the clinical response to IFN-beta treatment. IFN-beta induces SLC9A9 expression, resulting in inhibition of proinflammatory T lymphocytes. The findings suggest a key role for this gene in determining the response to IFN-beta in patients with multiple sclerosis.
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