Journal
JOURNAL OF BACTERIOLOGY
Volume 192, Issue 11, Pages 2929-2932Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.01652-09
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Funding
- German Research Foundation (DFG) [1273]
- Niedersachsischer Verein zur Bekampfung der Tuberkulose
- Swedish Medical Research Council
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At present, Salmonella is considered to express two peroxiredoxin-type peroxidases, TsaA and AhpC. Here we describe an additional peroxiredoxin, Tpx, in Salmonella enterica and show that a single tpx mutant is susceptible to exogenous hydrogen peroxide (H(2)O(2)), that it has a reduced capacity to degrade H(2)O(2) compared to the ahpCF and tsaA mutants, and that its growth is affected in activated macrophages. These results suggest that Tpx contributes significantly to the sophisticated defense system that the pathogen has evolved to survive oxidative stress.
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