Journal
JOURNAL OF BACTERIOLOGY
Volume 192, Issue 11, Pages 2933-2935Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.01639-09
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Funding
- National Institutes of Health [HL092774]
- Burroughs Wellcome Fund
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Prokaryotic ubiquitin-like protein (Pup) is a posttranslational modifier that targets proteins for degradation by the mycobacterial proteasome. We show that the disordered amino terminus of Pup is required for degradation, while the helical carboxyl terminus mediates its attachment to proteins. Thus, Pup has distinct regions that either interact with pupylation enzymes or initiate proteasomal degradation.
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