Journal
JOURNAL OF BACTERIOLOGY
Volume 191, Issue 18, Pages 5628-5633Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00510-09
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Funding
- NIH [RO1 AI-44856, AI-061505, RO1 AI44826]
- European Project StopLATENTTB [200999]
- European Project Mycomancy [LSHO-CT-2006-037566]
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The numerous sigma (sigma) factors present in Mycobacterium tuberculosis are indicative of the adaptability of this pathogen to different environmental conditions. In this report, we describe the M. tuberculosis sigma(B) regulon and the phenotypes of an M. tuberculosis sigB mutant strain exposed to cell envelope stress, oxidative stress, and hypoxia. The sigB mutant was especially defective in survival under hypoxic conditions in vitro, but it was not attenuated for growth in THP-1 cells or during mouse and guinea pig infection.
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