Journal
JOURNAL OF BACTERIOLOGY
Volume 191, Issue 13, Pages 4482-4484Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00221-09
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Funding
- German Research Foundation [TR34, SFB766, FOR449, GRK685, SPP1130]
- European Union [LSHM-CT-2004-512093]
- German Ministry of Education and Research
- Medical Faculty, University of Tubingen
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Skin-colonizing gram-positive bacteria produce wall teichoic acids (WTAs) or related glycopolymers for unclear reasons. Using a WTA-deficient Staphylococcus aureus mutant, we demonstrated that WTA confers resistance to antimicrobial fatty acids from human sebaceous glands by preventing fatty acid binding. Thus, WTA is probably important for bacterial skin colonization.
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