Journal
JOURNAL OF BACTERIOLOGY
Volume 191, Issue 8, Pages 2902-2905Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.01721-08
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Funding
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [AR-54023]
- National Institute of Allergy and Infectious Diseases [AI-72144, AI-59602]
- American Heart Association Scientist Development Grant
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Rrp2 is the sole sigma(54)-dependent transcriptional activator present in the Borrelia burgdorferi genome. We showed that recombinant Rrp2 binds to DNA in a sequence-nonspecific manner. During infection, Rrp2 activates sigma(54)-dependent rpoS expression without an apparent upstream enhancer element commonly associated with other sigma(54)-dependent transcriptional activators.
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