4.4 Article

A 5′ Leader Sequence Regulates Expression of Methanosarcinal CO Dehydrogenase/Acetyl Coenzyme A Synthase

Journal

JOURNAL OF BACTERIOLOGY
Volume 191, Issue 22, Pages 7123-7128

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00731-09

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Funding

  1. Department of Energy, Energy Biosciences Program [DE-FG02-93ER20106]
  2. National Science Foundation, Division of Cellular and Bioscience [MCB0110762]

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In vivo expression of CO dehydrogenase/acetyl coenzyme A synthase in Methanosarcina spp. is coordinately regulated in response to substrate by at least two mechanisms: differential transcription initiation and early elongation termination near the 3' end of a 371-bp leader sequence. This is the first report of regulation of transcription elongation in the Archaea.

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