4.4 Article

Campylobacter jejuni CsrA mediates oxidative stress responses, biofilm formation, and host cell invasion

Journal

JOURNAL OF BACTERIOLOGY
Volume 190, Issue 9, Pages 3411-3416

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.01928-07

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Funding

  1. NIAID NIH HHS [R01 AI055715-02, R01 AI058284-02, R01 AI058284-05, R01 AI055715-05, R01 AI058284-01A1, R01 AI058284-04, AI055715, R21 AI061026-01, R01 AI058284-03, R01 AI058284, R21 AI061026, R01 AI055715-01, R01 AI055715-04, AI058284, R01 AI055715-03, R01 AI055715] Funding Source: Medline

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The putative global posttranscriptional regulator csrA was mutated in Campylobacter jejuni 81-176. The csrA mutant was attenuated in surviving oxidative stress. CsrA also contributed to biofilm formation and adherence to and invasion of INT407 intestinal epithelial cells, suggesting a regulatory role for CsrA in C. jejuni pathogenesis.

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