Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 16, Issue 2, Pages 69-81Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3933
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Funding
- Indian Institute of Technology Kanpur
- Department of Science and Technology (India)
- Government of India
- Wellcome Trust/DBT India Alliance
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G protein-coupled receptors (GPCRs) are intricately involved in a diverse array of physiological processes and pathophysiological conditions. They constitute the largest class of drug target in the human genome, which highlights the importance of understanding the molecular basis of their activation, downstream signalling and regulation. In the past few years, considerable progress has been made in our ability to visualize GPCRs and their signalling complexes at the structural level. This is due to a series of methodological developments, improvements in technology and the use of highly innovative approaches, such as protein engineering, new detergents, lipidic cubic phase-based crystallization and microfocus synchrotron beamlines. These advances suggest that an unprecedented amount of structural information will become available in the field of GPCR biology in the coming years.
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