Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 16, Issue 11, Pages 665-677Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm4063
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Funding
- European Research Council
- Danish National Research Foundation [DNRF58]
- Lundbeck Foundation
- Novo Nordisk Foundation
- Novo Nordisk Fonden [NNF12OC0001211] Funding Source: researchfish
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Nonsense-mediated mRNA decay (NMD) is probably the best characterized eukaryotic RNA degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade mRNAs with translation termination codons that are positioned in abnormal contexts. However, NMD is not only part of a general cellular quality control system that prevents the production of aberrant proteins. Mammalian cells also depend on NMD to dynamically adjust their transcriptomes and their proteomes to varying physiological conditions. In this Review, we discuss how NMD targets mRNAs, the types of mRNAs that are targeted, and the roles of NMD in cellular stress, differentiation and maturation processes.
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