Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 16, Issue 7, Pages 393-405Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm4007
Keywords
-
Categories
Funding
- Cancer Research UK [C596/A10419]
- European Research Council [322842 METABOp53]
- Cancer Research UK [18274] Funding Source: researchfish
Ask authors/readers for more resources
The function of p53 as a tumour suppressor has been attributed to its ability to promote cell death or permanently inhibit cell proliferation. However, in recent years, it has become clear that p53 can also contribute to cell survival. p53 regulates various metabolic pathways, helping to balance glycolysis and oxidative phosphorylation, limiting the production of reactive oxygen species, and contributing to the ability of cells to adapt to and survive mild metabolic stresses. Although these activities may be integrated into the tumour suppressive functions of p53, deregulation of some elements of the p53-induced response might also provide tumours with a survival advantage.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available