Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 16, Issue 4, Pages 232-244Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3966
Keywords
-
Categories
Funding
- US National Institutes of Health (NIH) [DK105542, DK054441]
- Howard Hughes Medical Institute
Ask authors/readers for more resources
Cellular responses to environmental cues involve the mobilization of GTPases, protein kinases and phosphoprotein phosphatases. The spatial organization of these signalling enzymes by scaffold proteins helps to guide the flow of molecular information. Allosteric modulation of scaffolded enzymes can alter their catalytic activity or sensitivity to second messengers in a manner that augments, insulates or terminates local cellular events. This Review examines the features of scaffold proteins and highlights examples of locally organized groups of signalling enzymes that drive essential physiological processes, including hormone action, heart rate, cell division, organelle movement and synaptic transmission.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available