Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 16, Issue 8, Pages 486-498Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm4012
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Funding
- Packard Foundation
- American Asthma Foundation grant
- NSF-MCB [1344203]
- NSF-CMMI [1434095]
- Universite Paris-Sud
- CNRS
- Marie Curie Integration [PCIG12-GA-2012-334053]
- Investissements d'Avenir LabEx PALM [ANR-10-LABX-0039-PALM]
- University of Chicago FACCTS programme
- University of Chicago MRSEC [NSF-DMR 1420709]
- Div Of Molecular and Cellular Bioscience [1344203] Funding Source: National Science Foundation
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Actomyosin-mediated contractility is a highly conserved mechanism for generating mechanical stress in animal cells and underlies muscle contraction, cell migration, cell division and tissue morphogenesis. Whereas actomyosin-mediated contractility in striated muscle is well understood, the regulation of such contractility in non-muscle and smooth muscle cells is less certain. Our increased understanding of the mechanics of actomyosin arrays that lack sarcomeric organization has revealed novel modes of regulation and force transmission. This work also provides an example of how diverse mechanical behaviours at cellular scales can arise from common molecular components, underscoring the need for experiments and theories to bridge the molecular to cellular length scales.
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