Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 16, Issue 2, Pages 82-94Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3934
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01 GM111731] Funding Source: Medline
Ask authors/readers for more resources
The appropriate timing of events that lead to chromosome segregation during mitosis and cytokinesis is essential to prevent aneuploidy, and defects in these processes can contribute to tumorigenesis. Key mitotic regulators are controlled through ubiquitylation and proteasome-mediated degradation. The APC/C (anaphase-promoting complex; also known as the cyclosome) is an E3 ubiquitin ligase that has a crucial function in the regulation of the mitotic cell cycle, particularly at the onset of anaphase and during mitotic exit. Co-activator proteins, inhibitor proteins, protein kinases and phosphatases interact with the APC/C to temporally and spatially control its activity and thus ensure accurate timing of mitotic events.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available