Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 16, Issue 6, Pages 360-374Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm4002
Keywords
-
Categories
Funding
- European Research Council [233339]
- ARC
- Ligue Nationale Contre le Cancer (LNCC)
- European Research Council (ERC) [233339] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1-S-phase transition, pre-RCs are converted into pre-initiation complexes, in which the replicative helicase is activated, leading to DNA unwinding and initiation of DNA synthesis. However, only a subset of origins are activated during any S phase. Recent insights into the mechanisms underlying this choice reveal how flexibility in origin usage and temporal activation are linked to chromosome structure and organization, cell growth and differentiation, and replication stress.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available