Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 59, Issue 6, Pages 3615-3618Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.04474-14
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Funding
- Consejeria de Educacion, Universidades e Investigacion [GIC12 210-IT-696-13]
- Departamento de Industria, Comercio y Turismo of Gobierno Vasco-Eusko Jaurlaritza [S-PR12UN002, S-PE13UN121]
- Fondo de Investigacion Sanitaria [FIS PI11/00203]
- UPV/EHU [UFI 11/25]
- Universidad del Pais Vasco/Euskal Herriko Unibertsitatea
- Astellas Pharma
- Pfizer SLU
- Gilead Sciences
- Schering Plough
- Merck Sharp Dohme
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Anidulafungin, caspofungin, and micafungin killing activities against Candida glabrata, Candida bracarensis, and Candida nivariensis were evaluated by the time-kill methodology. The concentrations assayed were 0.06, 0.125, and 0.5 mu g/ml, which are achieved in serum. Anidulafungin and micafungin required between 13 and 26 h to reach the fungicidal endpoint (99.9% killing) against C. glabrata and C. bracarensis. All echinocandins were less active against C. nivariensis.
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