Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 16, Issue 11, Pages 643-649Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm4067
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Funding
- Wellcome Trust
- Lister Institute of Preventive Medicine
- Exeter College, University of Oxford, UK
- Junior Research Fellowship at St John's College, University of Oxford
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Polycomb group proteins are transcriptional repressors that are essential for normal gene regulation during development. Recent studies suggest that Polycomb repressive complexes (PRCs) recognize and are recruited to their genomic target sites through a range of different mechanisms, which involve transcription factors, CpG island elements and non-coding RNAs. Together with the realization that the interplay between PRC1 and PRC2 is more intricate than was previously appreciated, this has increased our understanding of the vertebrate Polycomb system at the molecular level.
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