Journal
JOURNAL OF AUTOIMMUNITY
Volume 40, Issue -, Pages 58-65Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jaut.2012.07.010
Keywords
Immune tolerance; Antigen-specific; Regulatory T cells; Non-transgenic mice; TCR transgenic mice; Human
Categories
Funding
- CIHR
- Diabete Quebec Award
- Foundation of the Maisonneuve-Rosemont Hospital
- Canadian Foundation for Innovation
- Natural Sciences and Engineering Research Council of Canada
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Double negative T cells that lack the expression of both CD4 and CD8 T cell co-receptors exhibit a most unique antigen-specific immunoregulatory potential first described over a decade ago. Due to their immunoregulatoty function, this rare T cell population has been studied in both mice and humans for their contribution to peripheral tolerance and disease prevention. Consequently, double negative cells are gaining interest as a potential cellular therapeutic. Herein, we review the phenotype and function of double negative T cells with emphasis on their capacity to induce antigen-specific immune tolerance. While the phenotypic and functional similarities between double negative T cells identified in mouse and humans are highlighted, we also call attention to the need for a specific marker of double negative T cells, which will facilitate future studies in humans. Altogether, due to their unique properties, double negative T cells present a promising therapeutic potential in the context of various disease settings. (C) 2012 Elsevier Ltd. All rights reserved.
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