Journal
JOURNAL OF AUTOIMMUNITY
Volume 34, Issue 2, Pages 155-162Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jaut.2009.08.014
Keywords
Scleroderma; Systemic sclerosis/SSc; Polymorphism/SNP; BLK; C8orf13; Anti-Topoisomerase I; Anti-centromere; Genetics; Autoantibody; rs13277113; rs2736340
Categories
Funding
- NIH/NIAMS Center of Research Translation (CORT) in Scleroderma [P50AR054144]
- NIH/NIAMS Scleroderma Family Registry and DNA Repository [N01-AR-0-2251]
- UTHSC-H Center for Clinical and Translational Sciences (NIH/NCRR) [3UL1RR024148]
- GENFER
- Fondo Social Europeo
- LandelijkKatholiekReuma Centrum (LKRC)
- [SAF2006-00398]
- [CTS-1180]
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Objective: Genetic studies in the systemic sclerosis (SSc), an autoimmune disease that clinically manifests with dermal and internal organ fibrosis and small vessel vasculopathy, have identified multiple susceptibility genes including HLA-class 11, PTPN22, IRF5, and STAT4 which have also been associated with other autoimmune diseases, such as systemic lupus erythematosus (SLE). These data suggest that there are common autoimmune disease susceptibility genes. The current report sought to determine if polymorphisms in the C8orf13-BLK region (chromosome 8p23.1-B lymphoid tyrosine kinase), which is associated with SLE, are associated also with SSc. Methods: Two variants in the C8orf13-BLK region (rs13277113 & rs2736340) were tested for association with 1050 SSc cases and 694 controls of North Americans of European descent and replicated in a second series 589 SSc cases and 722 controls from Spain. Results: The T allele at rs2736340 variant was associated with SSc in both the U.S. and Spanish case-control series (P = 6.8 x 10(-5), OR 1.27, 95% Cl 1.1-1.4). The A allele at rs13277113 variant was associated with SSc in the U.S. series only (P = 3.6 x 10(-4), OR 1.32, 95% Cl 1.1-1.6) and was significant in the combined analyses of the two series (P = 2.0 x 10(-3); OR 1.20, 95% Cl 1.1-1.3). Both variants demonstrated an association with the anti-centromere antibody (P = 2.2 x 10(-6) and P = 5.5 x 10(-4), respectively) and limited SSc (P = 3.3 x 10(-5) and P = 2.9 x 10(-3), respectively) in the combined analysis. Peripheral blood gene expression profiles suggest that B-cell receptor and NF kappa B signaling are dysregulated based on the risk haplotype of these variants. Conclusion: We identify and replicate the association of the C8orf13-BLK region as a novel susceptibility factor for SSc, placing it in the category of common autoimmune disease susceptibility genes. (C) 2009 Elsevier Ltd. All rights reserved.
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