Journal
NATURE REVIEWS MICROBIOLOGY
Volume 13, Issue 6, Pages 360-372Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrmicro3451
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Funding
- US National Institutes of Health [R01HG005969, U54DK102557]
- US National Science Foundation [DBI-1053486]
- US Army Research Office [W911NF-11-1-0473]
- Danone Research grant [PLF-5972-GD]
- Direct For Biological Sciences
- Div Of Biological Infrastructure [GRANTS:13977089, 1053486] Funding Source: National Science Foundation
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High-throughput DNA sequencing has proven invaluable for investigating diverse environmental and host-associated microbial communities. In this Review, we discuss emerging strategies for microbial community analysis that complement and expand traditional metagenomic profiling. These include novel DNA sequencing strategies for identifying strain-level microbial variation and community temporal dynamics; measuring multiple 'omic' data types that better capture community functional activity, such as transcriptomics, proteomics and metabolomics; and combining multiple forms of omic data in an integrated framework. We highlight studies in which the 'multi-omics' approach has led to improved mechanistic models of microbial community structure and function.
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