Journal
JOURNAL OF AUTOIMMUNITY
Volume 31, Issue 3, Pages 252-256Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jaut.2008.04.017
Keywords
Th1; Th17; IL-17; IFN-gamma; Autoimmunity
Categories
Funding
- NIAID NIH HHS [P01 AI039671, R01 AI044880] Funding Source: Medline
- NINDS NIH HHS [R37 NS030843-14, R01 NS035685, R37 NS030843-15, R01 NS035685-08, R01 NS035685-09, R37 NS030843, R01 NS035685-07, R37 NS030843-16] Funding Source: Medline
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CD4(+) IFN-gamma-producing Th1 cells have long been associated with the pathogenesis of many organ-specific autoimmune diseases; however, the observation of disease in mice deficient in molecules involved in Th1 cell differentiation raised the possibility that other effector T cells were responsible for inducing autoimmunity. Recently, a new CD4(+) effector T cell subset that produces IL-17 (Th17) has emerged. The fact that Th17 cells are highly auto-pathogenic has fueled a debate as to what role, if any, Th1 cells play in the induction of tissue inflammation and autoimmune disease. This review will discuss the respective roles of the Th1 and Th17 subsets in organ-specific autoimmunity. (C) 2008 Elsevier Ltd. All rights reserved.
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