Journal
NATURE REVIEWS MICROBIOLOGY
Volume 14, Issue 2, Pages 106-117Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro.2015.6
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Funding
- European Research Council
- Medical Research Council
- Lister Institute
- Royal Society
- US National Institutes of Health (NIH) [AI007313]
- University of Minnesota Doctoral Dissertation Fellowship
- Dennis W. Watson Fellowship
- NIH
- Wellcome Trust
- Medical Research Council (UK)
- Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology
- Medical Research Council [MR/J008176/1] Funding Source: researchfish
- MRC [MR/J008176/1] Funding Source: UKRI
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Cryptococcosis is a globally distributed invasive fungal infection that is caused by species within the genus Cryptococcus which presents substantial therapeutic challenges. Although natural human-to-human transmission has never been observed, recent work has identified multiple virulence mechanisms that enable cryptococci to infect, disseminate within and ultimately kill their human host. In this Review, we describe these recent discoveries that illustrate the intricacy of host-pathogen interactions and reveal new details about the host immune responses that either help to protect against disease or increase host susceptibility. In addition, we discuss how this improved understanding of both the host and the pathogen informs potential new avenues for therapeutic development.
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