Journal
JOURNAL OF AUTOIMMUNITY
Volume 31, Issue 3, Pages 257-262Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jaut.2008.04.009
Keywords
Cell clearance; Lupus; Autoantibodies
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Funding
- NIDDK NIH HHS [R37 DK039588-21, R37 DK039588] Funding Source: Medline
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The clearance of apoptotic cells is a highly regulated mechanism, normally associated with anti-inflammatory response. During early stages of apoptosis the cell is promptly recognized and engulfed by professional phagocytes or tissue cells to avoid the outflow of intracellular content and limit the immunological reaction against released antigens. However, increasing evidences suggest that impairment in the uptake of apoptotic cell debris is linked to the development of autoimmunity. In fact, autoantigens have been demonstrated to be content within apoptotic bodies and apoptotic cells seems to be critical in the presentation of antigens, activation of innate immunity and regulation of macrophage cytokine secretion. We herein review the known mechanisms for regulating the uptake of the products of apoptosis in the development of autoimmunity. (C) 2008 Elsevier Ltd. All rights reserved.
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