Journal
NATURE REVIEWS MICROBIOLOGY
Volume 13, Issue 9, Pages 529-543Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro3521
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Funding
- US National Institute of Allergy and Infectious Diseases [AI038897, AI052747, AI110937]
- American Heart Association [PST4590023]
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Staphylococcus aureus, a bacterial commensal of the human nares and skin, is a frequent cause of soft tissue and bloodstream infections. A hallmark of staphylococcal infections is their frequent recurrence, even when treated with antibiotics and surgical intervention, which demonstrates the bacterium's ability to manipulate innate and adaptive immune responses. In this Review, we highlight how S. aureus virulence factors inhibit complement activation, block and destroy phagocytic cells and modify host B cell and T cell responses, and we discuss how these insights might be useful for the development of novel therapies against infections with antibiotic resistant strains such as methicillin-resistant S. aureus.
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