Journal
NATURE REVIEWS MICROBIOLOGY
Volume 13, Issue 11, Pages 707-721Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrmicro3568
Keywords
-
Categories
Funding
- US National Institute of General Medical Sciences [GMO22854, GM115431]
- Natural Sciences and Engineering Research Council of Canada [RGPIN 04282-2014]
- Canadian Institutes of Health Research Tier 2 Canada Research Chair [950-229917]
- The University of Texas Health Science Center at Houston start-up fund
Ask authors/readers for more resources
The genetic code, initially thought to be universal and immutable, is now known to contain many variations, including biased codon usage, codon reassignment, ambiguous decoding and recoding. As a result of recent advances in the areas of genome sequencing, biochemistry, bioinformatics and structural biology, our understanding of genetic code flexibility has advanced substantially in the past decade. In this Review, we highlight the prevalence, evolution and mechanistic basis of genetic code variations in microorganisms, and we discuss how this flexibility of the genetic code affects microbial physiology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available