Journal
NATURE REVIEWS GENETICS
Volume 17, Issue 2, Pages 71-80Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrg.2015.8
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Funding
- Biotechnology and Biosciences Research Council (UK) [BB/J009709/1]
- National Evolutionary Synthesis Center, USA
- National Science Foundation [EF-0905606]
- Biotechnology and Biological Sciences Research Council [BB/N000919/1, BB/J009709/1, BB/J00538X/1, BB/G006660/1] Funding Source: researchfish
- BBSRC [BB/J009709/1, BB/J00538X/1, BB/G006660/1] Funding Source: UKRI
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Five decades have passed since the proposal of the molecular clock hypothesis, which states that the rate of evolution at the molecular level is constant through time and among species. This hypothesis has become a powerful tool in evolutionary biology, making it possible to use molecular sequences to estimate the geological ages of species divergence events. With recent advances in Bayesian clock dating methodology and the explosive accumulation of genetic sequence data, molecular clock dating has found widespread applications, from tracking virus pandemics and studying the macroevolutionary process of speciation and extinction to estimating a timescale for life on Earth.
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