Journal
NATURE REVIEWS GENETICS
Volume 16, Issue 12, Pages 716-726Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3980
Keywords
-
Categories
Funding
- European Research Council
- Israel Science Foundation
- Flight Attendant Medical Research Institute
Ask authors/readers for more resources
Epigenomics is the study of the physical modifications, associations and conformations of genomic DNA sequences, with the aim of linking these with epigenetic memory, cellular identity and tissue-specific functions. While current techniques in the field are characterizing the average epigenomic features across large cell ensembles, the increasing interest in the epigenetics within complex and heterogeneous tissues is driving the development of single-cell epigenomics. We review emerging single-cell methods for capturing DNA methylation, chromatin accessibility, histone modifications, chromosome conformation and replication dynamics. Together, these techniques are rapidly becoming a powerful tool in studies of cellular plasticity and diversity, as seen in stem cells and cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available