Journal
NATURE REVIEWS GENETICS
Volume 16, Issue 8, Pages 483-496Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3949
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Funding
- Agence Nationale pour la Recherche [12-BSV2-0004-01]
- Coup d'Elan from the Bettencourt-Schueller Foundation
- Biotechnology and Biological Sciences Research Council (BBSRC) in the UK [BB/L021455/1]
- Biotechnology and Biological Sciences Research Council [BB/L021455/1] Funding Source: researchfish
- BBSRC [BB/L021455/1] Funding Source: UKRI
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Robustness is characterized by the invariant expression of a phenotype in the face of a genetic and/or environmental perturbation. Although phenotypic variance is a central measure in the mapping of the genotype and environment to the phenotype in quantitative evolutionary genetics, robustness is also a key feature in systems biology, resulting from nonlinearities in quantitative relationships between upstream and downstream components. In this Review, we provide a synthesis of these two lines of investigation, converging on understanding how variation propagates across biological systems. We critically assess the recent proliferation of studies identifying robustness-conferring genes in the context of the nonlinearity in biological systems.
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