Journal
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
Volume 17, Issue 5, Pages 431-435Publisher
JAPAN ATHEROSCLEROSIS SOC
DOI: 10.5551/jat.3525
Keywords
SIRT1; Vascular senescence; Dysfunction; Atherosclerosis
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Funding
- Ministry of Education, Science, Culture and Sports of Japan [20249041, 18590801, 18890056]
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Sir2 (silent information regulator-2), an NAD(+)-dependent histone deacetylase, is highly conserved in organisms ranging from archaea to humans. Yeast Sir2 is responsible for silencing at repeated DNA sequences in mating-type loci, telomeres and rDNA, and plays critical roles in DNA repair, stress resistance and longevity. The phenomenon of human aging is known to be a critical cardiovascular risk factor. Senescence of endothelial cells has been proposed to be involved in vascular dysfunction and atherogenesis. Recent studies have demonstrated that mammalian Sirt1 NAD(+)-dependent protein deacetylase, the closest homologue of Sir2, regulates vascular angiogenesis, homeostasis and senescence. This review focuses on SIRT1 as a potential therapeutic target against atherosclerosis.
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