Serum anti-Mullerian hormone levels correlate with ovarian response in idiopathic hypogonadotropic hypogonadism

The role of serum AMH levels in prediction of ovarian response in idiopathic hypogonadotropic hypogonadism (IHH) was evaluated. Twelve patients with IHH underwent controlled ovarian hyperstimulation (COH) for IVF were enrolled in this prospective study. Serum AMH levels were studied on the 2nd or 3rd day of an induced menstrual cycle by a preceding low-dose oral contraceptive pill treatment. A fixed dose (150-300 IU/day) of hMG was given in all COH cycles. Correlations between serum AMH levels, COH outcomes and embryological data were investigated. Mean serum AMH levels was 3.47 +/- 2.15 ng/mL and mean serum peak estradiol was 2196 +/- 1705 pg/mL. Mean number of follicles > 14 mm, > 17 mm on hCG day and MII oocytes were 4.14 +/- 3.2, 4 +/- 2.5 and 7.28 +/- 3.5, respectively. Mean number of grade A embryos and transferred embryos were 3.28 +/- 2.4 and 2.5 +/- 0.7, respectively. The clinical pregnancy rate per patient was 41.6 % (5/12). Positive correlations were observed between serum AMH levels and MII oocytes (r = 0.84), grade A embryos (r = 0.85), serum peak estradiol levels (r = 0.87), and number of follicles > 14 mm (r = 0.83) and > 17 mm (r = 0.81) on hCG day, respectively. AMH appears as a promising marker of ovarian response in patients with IHH undergoing IVF.