Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 15, Issue 1, Pages 19-34Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd.2015.5
Keywords
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Funding
- Canadian Institutes of Health Research
- Alberta Innovates: Health Solutions
- Natural Sciences and Engineering Research Council of Canada
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Voltage-gated calcium channels are important regulators of brain, heart and muscle functions, and their dysfunction can give rise to pathophysiological conditions ranging from cardiovascular disorders to neurological and psychiatric conditions such as epilepsy, pain and autism. In the nervous system, calcium channel blockers have been used successfully to treat absence seizures, and are emerging as potential therapeutic avenues for pathologies such as pain, Parkinson disease, addiction and anxiety. This Review provides an overview of calcium channels as drug targets for nervous system disorders, and discusses potential challenges and opportunities for the development of new clinically effective calcium channel inhibitors.
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