4.4 Article

The effects of metformin or orlistat on obese women with polycystic ovary syndrome: a prospective randomized open-label study

Journal

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
Volume 28, Issue 7, Pages 591-596

Publisher

SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10815-011-9564-2

Keywords

Metformin; Orlistat; PCOS; Weight loss; Waist circumference

Funding

  1. Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences and Sabzevar University of Medical Sciences, Sabzevar, Iran

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Purpose Comparing the effects of metformin or orlistat on hormone, lipid profile and ovulation status in obese women with polycystic ovary syndrome. Methods A total of 80 women were prospectively recruited to receive either metformin (n = 40) or orlistat (n = 40). Weight, BMI, waist, serum LH, total serum testosterone and lipid profile were assessed at baseline and after 3 months. The subjects' ovulatory status was assessed after 3 months. Results There was no significant difference in ovulation between the two treatment groups (30% vs 15%). Treatment with either drug showed a significant decline in body weight, BMI (Body Mass Index), and waist circumference, but the degree of decline in both groups was the same. Patients who were treated with orlistat, showed a significant reduction in total testosterone and serum lipid. Women in metformin group showed a significant reduction in serum LH. Conclusions Both metformin and orlistat showed a similar effect on weight loss and ovulation rates.

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