Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 16, Issue 4, Pages 351-357Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2013.879469
Keywords
anti-inflammatory activity; degranulation; leukotriene C4; polyhydroxylated steroids; mouse bone marrow-derived mast cells; Echinogorgia sassapo reticulata
Funding
- National Natural Science Foundation of China [81102371]
- Natural Science Foundation of Tianjin, China [10JCYBJC15000]
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The gorgonian Echinogorgia sassapo reticulata contains two new bioactive polyhydroxylated steroids, sassapols A (1), B (2), and five related known compounds (3-7). Compound 6 has been encountered for the first time in natural sources. The structures of these new compounds were defined by spectroscopic analysis. All the compounds (1-7) isolated from E. sassapo reticulata were tested for anti-inflammatory activity. Compounds 1, 3, 5, and 7 inhibited both the generation of leukotriene C-4 and the degranulation reaction in mouse bone marrow-derived mast cells.
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