Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 17, Issue 4, Pages 319-323Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2014.980240
Keywords
Gliomastix murorum; dihydroxanthenone; structure elucidation; cytotoxicity
Funding
- National Natural Science Foundation of China [21462051]
- Applied Basic Research Combined Project of Yunnan Technology Bureau [2011FB124]
- Kunming Medical University [2011FB124]
- Scientific Research Fund Key Project of Education Department of Yunnan Province [2013Z038]
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Three new dihydroxanthones, muroxanthenones A-C (1-3), together with three known dihydroxanthones (4-6) were isolated from the fermentation products of an endophytic fungus Gliomastix murorum. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compound 3 showed high cytotoxicities against NB4 and PC3 cell with IC50 values of 2.2 and 2.8 mu M. The other compounds also showed moderate cytotoxicities for some tested cell lines with IC50 values between 4.1 and 9.5 mu M.
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