Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 16, Issue 12, Pages 1153-1157Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2014.959438
Keywords
biological activity; insect pathogenic fungi; Paecilomyces verticillatus; verticilatin
Funding
- National Natural Science Foundation of China [31171885, 31371957]
- Changjiang Scholars and Innovative Research Team in University [IRT1124]
- Ph.D. Programs Foundation of Ministry of Education of China [20121301110006]
- Key Projects in the Hebei Province Science Technology [13226508D]
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A novel oxybis cresol compound named verticilatin (1), together with two known compounds, 5-methylresorcinol (2) and 2,4-dihydroxy-3,6-dimethylbenzaldehyde (3), was isolated from cultures of the insect pathogenic fungi Paecilomyces verticillatus. The structures of compounds were determined by extensive spectroscopic analysis of HR-ESI-MS and 1D and 2D NMR including HSQC, HMBC, COSY, and ROESY. Fortunately, compound 1 exhibited significant inhibitory activities against CDC25B, cathepsin B, MEG2, and SHP2 enzyme, with IC50 values of 11.5, 3.5, 7.8, and 15 mu g/ml, respectively.
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