Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 15, Issue 9, Pages 979-984Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2013.822368
Keywords
Uraria clarkei; flavane; cytotoxicity; (2R)-4 '-hydroxy-2 ',5,7-trimethoxyflavan; (2R,4R)-2 ',4 '-dihydroxy-5,7-dimethoxyflavan-4-ol
Funding
- National Natural Science Foundation of China (NSFC) [21162041, 21262047]
- Science Foundation of the Education Department of Yunnan Province [2012J071]
- Independent Innovation Project for postgraduates from the Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission [11HXYJS03, 2011HXDZB04]
- Ministry of Education, Yunnan University of Nationalities
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Two new flavanes, (2R)-4-hydroxy-2,5,7-trimethoxyflavane (1) and (2R,4R)-2,4-dihydroxy-5,7-dimethoxyflavan-4-ol (2), were isolated from Uraria clarkei, together with two known compounds 5,7-dimethoxy-4-hydroxyflavan (3) and 5,7,4-trimethoxyflavan (4). The structures of the new flavanes were characterized by analyses of the MS, IR, UV, CD, 1D, and 2D NMR data. Cytotoxicity test suggested that compounds 1-4 possessed slight activity against K-562 and Hela cell lines, with the IC50 values ranging from 26.6 to 56.3M.
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