Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 15, Issue 1, Pages 71-77Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2012.723202
Keywords
Araceae; Arisaema franchetianum; alkaloids; C21 steroids; porcine respiratory and reproductive syndrome virus; cytotoxicity
Funding
- National Natural Science Foundation of China [20972166, 31160509, 31161140345, 31070288]
- Yunnan Provincial Program for Excellent Scientists [2009CI125]
- Key Research Direction Project of Knowledge Innovation Program for Chinese Academy of Sciences [KSCX2-EW-J-24]
- Ministry of Education of China [B08044, MUC985-9, MUC98506-01000101]
Ask authors/readers for more resources
A novel pyrrolidine alkaloid, (2R*,3S*,5S*)-N,2-dimethyl-3-hydroxy-5-(10-phenyldecyl)pyrrolidine (1), and 17 known compounds were isolated from Arisaema franchetianum Engl. (Araceae) tubers. The 17 compounds were bergenin (2), emodin (3), caffeic acid (4), nobiletin (5), 3-O--d-galactopyranosyl-hederagenin 28-O--d-xylopyranosyl(16)--d-galactopyranosyl ester (6), coniferin (7), qingyangshengenin (8), methylconiferin (9), syringaresinol 4-O--d-glucopyranoside (10), gagaminine (11), perlolyrine (12), (S)-1-(1-hydroxyethyl)--carboline (13), 1-(-carboline-1-yl)-3,4,5-trihydroxy-1-pentanone (14), 1-methoxycarbonyl--carboline (15), indolo[2,3-]carbazole (16), 4-hydroxycinnamic acid methyl ester (17), and methyl 4-[2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl)ethyl] ferulate (18). The inhibitory activities of compound 1 and its N-methyl derivative (1a) against porcine respiratory and reproductive syndrome virus (PRRSV), human leukemic K562 cells, and human breast cancer MCF-7 cells were evaluated. Compounds 1 [50% inhibited concentration (IC50)=12.5 +/- 0.6M] and 1a (IC50=15.7 +/- 0.9M) were cytotoxic against K562 cells. Compound 1a also had a weak effect on PRRSV with an IC50 value of 31.9 +/- 6.0M [selectivity index (SI)=18.7].
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available