Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 14, Issue 11, Pages 1064-1072Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2012.708657
Keywords
curcumin; praziquantel; Schistosoma japonicum; in vitro
Funding
- Natural Science Fund of Jiangsu Province [BK2009076]
- Graduate Student Research and Innovation Program of Jiangsu Province [CXLX11-0078]
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Curcumin is a polyphenol derived from the dietary spice turmeric. The aim of this study was to investigate the in vitro effect of curcumin against eggs, cercariae, pre-adults, and adults of Schistosoma japonicum compared to praziquantel. After incubated by different concentration of curcumin or praziquantel in different time, the percent hatching rates of eggs, the percent dead rates of cercariae, and the number of dead worms were observed. Curcumin showed time- and dose-dependent schistosomicidal effects on every life stages of S. japonicum. In addition, curcumin exhibited an optimal activity against the adult stage with no differential sensitivity between male and female worms and decreased motor activity of these worms without tegumental alterations. The promising in vitro effects on all stages of S. japonicum warrants further evaluation for the prophylactic and therapeutic values in the early and late schistosomiasis in field trials.
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